Scaffold Design for Bone Regeneration

Advanced Nanocomposite Scaffold for Bone Regeneration

Introduction Each year in the United States approximately 500,000 procedures that involve the use of bone substitutes are performed. To address the limitations of materials currently used in orthopaedic tissue engineering, we have developed novel nanocomposite materials that consist of a citric acid-based elastomer, poly(1,8 octanediol citrate) (POC) and bioceramic nanoparticles, βtricalcium ph...

Surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold.

The goal of this study was to investigate if the preparation of implantation site affects bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats before the insertion of a bone scaffold: a manually driven wood drill bit and an electrically driven metal drill bit. The size and the position of the ...

design of polycaprolactone nanofibrous scaffold as suitable substrate for limbal stem cells for corneal epithelial regeneration

purpose: to develop a nanofibrous polycaprolacton (pcl) substrate for limbal stem cell (lsc) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. methods: the human limbal stem cells (lscs) were used to evaluate the biocompatibility of substrates (nanofibrous scaffold, and human amniotic membrane) regarding cellular phenotypic profile, viability, pro...

Effect of polycaprolactone scaffold permeability on bone regeneration in vivo.

Successful bone tissue engineering depends on the scaffold's ability to allow nutrient diffusion to and waste removal from the regeneration site, as well as provide an appropriate mechanical environment. Since bone is highly vascularized, scaffolds that provide greater mass transport may support increased bone regeneration. Permeability encompasses the salient features of three-dimensional poro...

A Preclinical Evaluation of the Functionalized Biphasic Silk Fibroin Scaffold for Complete Bone-Ligament-Bone Regeneration